:root{
  --bg:#f6f8fa; --panel:#ffffff; --ink:#1f2937; --muted:#6b7280;
  --line:#e5e7eb; --brand:#1d4e89; --brand2:#2f7bbf; --accent:#0f766e;
  --ko:#c0392b; --kd:#d68910; --oe:#7d3c98; --ki:#1f618d; --control:#566573; --treatment:#117a65;
}
*{box-sizing:border-box}
body{margin:0;font-family:-apple-system,"Segoe UI",Roboto,"Helvetica Neue","Hiragino Kaku Gothic ProN","Noto Sans JP",sans-serif;
  color:var(--ink);background:var(--bg);line-height:1.5}
a{color:var(--brand2);text-decoration:none}
a:hover{text-decoration:underline}

/* ---- mock banner ---- */
.mockbar{background:#fff7ed;border-bottom:1px solid #fdba74;color:#9a3412;
  font-size:13px;text-align:center;padding:6px 12px}

/* ---- header ---- */
header.nav{background:var(--brand);color:#fff;padding:14px 24px;display:flex;align-items:center;gap:24px}
header.nav .logo{font-weight:700;font-size:20px;letter-spacing:.5px;color:#fff;text-decoration:none}
header.nav .logo:hover{text-decoration:none;opacity:.9}
header.nav .logo small{font-weight:400;opacity:.8;font-size:12px;margin-left:8px}
header.nav nav{margin-left:auto;display:flex;gap:20px}
header.nav nav a{color:#dbeafe;font-size:14px}
header.nav nav a:hover{color:#fff}

.wrap{max-width:1100px;margin:0 auto;padding:24px}

/* ---- hero / search ---- */
.hero{background:linear-gradient(135deg,#1d4e89,#2f7bbf);color:#fff;padding:46px 24px;text-align:center}
.hero h1{margin:0 0 6px;font-size:30px}
.hero p{margin:0 auto 22px;max-width:680px;opacity:.92}
.searchbox{max-width:680px;margin:0 auto;display:flex;background:#fff;border-radius:10px;overflow:hidden;box-shadow:0 8px 24px rgba(0,0,0,.18)}
.searchbox input{flex:1;border:0;padding:15px 18px;font-size:16px;color:var(--ink)}
.searchbox input:focus{outline:none}
.searchbox button{border:0;background:var(--accent);color:#fff;padding:0 22px;font-size:15px;cursor:pointer}
.hint{margin-top:10px;font-size:13px;opacity:.85}
.hint a{color:#fff;text-decoration:underline;cursor:pointer}

/* ---- stat cards ---- */
.cards{display:grid;grid-template-columns:repeat(4,1fr);gap:16px;margin:28px 0}
.card{background:var(--panel);border:1px solid var(--line);border-radius:10px;padding:18px;text-align:center}
.card .num{font-size:26px;font-weight:700;color:var(--brand)}
.card .lbl{font-size:13px;color:var(--muted);margin-top:4px}

/* ---- section ---- */
h2.sec{font-size:18px;border-left:4px solid var(--brand2);padding-left:10px;margin:30px 0 14px}

/* ---- label distribution bars ---- */
.dist{background:var(--panel);border:1px solid var(--line);border-radius:10px;padding:18px}
.dist .row{display:flex;align-items:center;gap:12px;margin:7px 0}
.dist .row .name{width:90px;font-size:13px;font-weight:600}
.dist .row .track{flex:1;background:#eef1f4;border-radius:6px;height:18px;overflow:hidden}
.dist .row .fill{height:100%;border-radius:6px}
.dist .row .val{width:70px;text-align:right;font-size:12px;color:var(--muted)}

/* ---- tables ---- */
table{width:100%;border-collapse:collapse;background:var(--panel);border:1px solid var(--line);border-radius:10px;overflow:hidden}
th,td{padding:10px 12px;text-align:left;font-size:13.5px;border-bottom:1px solid var(--line)}
th{background:#f0f3f6;color:#374151;font-weight:600;font-size:12.5px;text-transform:uppercase;letter-spacing:.3px}
tr:last-child td{border-bottom:0}
tr:hover td{background:#fafbfc}
td.mono,th.mono{font-family:ui-monospace,SFMono-Regular,Menlo,monospace;font-size:12.5px}

/* ---- label badges ---- */
.badge{display:inline-block;padding:2px 9px;border-radius:20px;font-size:12px;font-weight:600;color:#fff}
.b-KO{background:var(--ko)} .b-KD{background:var(--kd)} .b-OE{background:var(--oe)}
.b-KI{background:var(--ki)} .b-Control{background:var(--control)} .b-Treatment{background:var(--treatment)}
.b-Unknown{background:#9aa0a6}
.badge.sm{font-size:10.5px;padding:1px 7px}
.gene{font-style:italic}
.muted{color:var(--muted)}
.src{font-size:11px;color:var(--muted);border:1px solid var(--line);border-radius:4px;padding:1px 5px}

/* ---- 6-axis bars (run detail) ---- */
.axes{background:var(--panel);border:1px solid var(--line);border-radius:10px;padding:18px;max-width:560px}
.axes .ax{display:flex;align-items:center;gap:12px;margin:9px 0}
.axes .ax .n{width:90px;font-size:13px;font-weight:600}
.axes .ax .t{flex:1;background:#eef1f4;border-radius:6px;height:16px;overflow:hidden}
.axes .ax .f{height:100%;border-radius:6px}
.axes .ax .s{width:46px;text-align:right;font-size:12px;color:var(--muted)}

/* ---- detail meta ---- */
.meta{background:var(--panel);border:1px solid var(--line);border-radius:10px;padding:18px;margin-bottom:18px}
.meta dl{display:grid;grid-template-columns:160px 1fr;gap:8px 16px;margin:0}
.meta dt{color:var(--muted);font-size:13px}
.meta dd{margin:0;font-size:14px}

/* ---- download ---- */
.dlgrid{display:grid;grid-template-columns:repeat(2,1fr);gap:16px}
.dlcard{background:var(--panel);border:1px solid var(--line);border-radius:10px;padding:20px}
.dlcard h3{margin:0 0 6px;font-size:16px}
.dlcard p{color:var(--muted);font-size:13.5px;margin:0 0 14px}
.btnrow{display:flex;gap:10px;flex-wrap:wrap}
.btn{display:inline-block;background:var(--brand2);color:#fff;padding:8px 14px;border-radius:7px;font-size:13px;cursor:pointer;border:0}
.btn.alt{background:#fff;color:var(--brand2);border:1px solid var(--brand2)}
.doi{margin-top:18px;background:#ecfdf5;border:1px solid #a7f3d0;border-radius:8px;padding:12px 16px;font-size:13.5px}

footer{color:var(--muted);font-size:12.5px;text-align:center;padding:30px 16px;border-top:1px solid var(--line);margin-top:30px}

/* ---- about ---- */
.toc{background:var(--panel);border:1px solid var(--line);border-radius:10px;padding:12px 16px;margin-bottom:22px;font-size:13.5px;line-height:2}
.toc b{color:var(--muted);font-weight:600;margin-right:8px}
.toc a{margin-right:14px;white-space:nowrap}
.prose{font-size:14.5px;max-width:880px}
.prose p{margin:8px 0}
.prose ul{max-width:880px;font-size:14.5px}
.tbd{display:inline-block;background:#fef3c7;border:1px solid #fcd34d;color:#92400e;border-radius:4px;padding:1px 6px;font-size:11px;margin-left:6px;vertical-align:middle}
.license{background:#ecfdf5;border:1px solid #a7f3d0;border-radius:8px;padding:14px 18px;font-size:14px;max-width:880px}
.crumbs{font-size:13px;color:var(--muted);margin-bottom:14px}
.empty{padding:30px;text-align:center;color:var(--muted)}
.filterbar{display:flex;gap:10px;flex-wrap:wrap;align-items:center;margin-bottom:14px}
.filterbar input,.filterbar select{padding:8px 10px;border:1px solid var(--line);border-radius:7px;font-size:13.5px}
.filterbar input{flex:1;min-width:200px}

/* Provenance テーブル（根拠の元属性） */
table.prov{border-collapse:collapse;font-size:13px;margin:2px 0 4px}
table.prov td{border:1px solid #e0e0e0;padding:3px 8px;vertical-align:top}
table.prov td.mono{font-family:monospace;color:#555;white-space:nowrap;background:#fafafa}